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This research aims to understand the neural mechanisms regulating the timing of torpor as a survival strategy in mice.

May 25, 2026Nature CommunicationsOpen Access

GABAergic projections from the suprachiasmatic nucleus to the preoptic area regulate the timing of torpor in mice

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Randomized trial shows GABA signaling affects torpor timing in female mice, suggesting neural connections play a vital role in survival.

This research aims to understand the neural mechanisms regulating the timing of torpor as a survival strategy in mice.
Utilized optogenetic activation of GABAergic neurons in the SCN targeting the POA.
Performed retrograde tracing to identify connections between SCN and POA neurons.
Examined effects of selective deletion of vesicular GABA transporter in Avp neurons.
Activation of GABAergic neurons suppressed torpor induction in female mice.
Disconnection of neural output in the SCN abolished the timing of torpor.
Deletion of vesicular GABA transporter in Avp neurons led to impaired torpor induction.

Rahaman et al. (2026) studied this question.

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