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May 25, 2026OncoTargets and Therapy0 citationsOpen Access

Bergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis Retraction

ZZZhongfang ZhaoNLNong Liao

Key Points

  • To assess the effects of bergamottin on DNA damage and progression in melanoma via the miR-145/cyclin D1 axis.
  • Data integrity issues raised post-publication
  • Investigation confirmed similarities in cell staining and flow cytometry plots
  • Authors acknowledged fundamental errors and requested retraction.
  • All findings were deemed invalid due to data integrity concerns.
  • Figures 2, 3B, 5, 6F, and 7 were retracted due to unexpected similarities.
  • Errors identified in Western blot and immunohistochemistry also contributed to concerns.

Abstract

Zhao Z, Liao N. Onco Targets Ther. 2021;14:37693781. https://doi.org/10.2147/OTT.S275322 We, the Editors and Publisher of the journal OncoTargets and Therapy, have retracted the published article. After publication, concerns have been raised by a third party in 2026 about the integrity of the data in Figures 2, 5, 6, and 7 of the article. Further investigation conducted by the Journal and Publisher confirmed the following: Unexpected similarities between the cell staining images in Figure 2 that are representative of different samples and treatment conditions Unexpected similarities between the flow cytometry plots in Figures 3B and 6F that are representative of different samples and treatment conditions Unexpected similarities between the Western blots in Figures 5G and 6B that are representative of different samples and treatment conditions Unexpected similarities between the immunohistochemistry staining images in Figure 7 that are representative of different samples and treatment conditions When informed that concerns had been raised, the authors checked their data and confirmed there are fundamental errors present. The authors have requested the retraction of this article and apologise for the errors. We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as Retracted.

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a13e7430e02ee3982d31edchttps://doi.org/10.2147/ott.s625401
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