Schiff base chromones from natural Benzofuran as potential scaffold for anti- Staphylococcus aureus : synthesis of cis and trans isomers, in vitro and in silico studies

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This study aims to explore Schiff base chromones derived from natural benzofuran as potential anti-Staphylococcus aureus agents.
Synthesis of cis and trans isomers of Schiff base chromones.
In vitro studies to assess antimicrobial activity against Staphylococcus aureus.
In silico studies targeting the DHPS enzyme active site.
Identified several Schiff base chromones with significant activity against Staphylococcus aureus.
Demonstrated a strong binding affinity to the DHPS enzyme in silico.
In vitro testing showed a 70% reduction in bacterial growth at certain concentrations.

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Evaluates anti-Staphylococcus aureus activity of Schiff base chromones in vitro and in silico, suggesting potential therapeutic applications.

and pteroic acid which suggest the possibility of these classes to act on DHPS enzyme.

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Ahmed A.M.A. Selim (2026) studied this question.

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