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May 25, 2026Experimental Eye Research0 citationsOpen Access

Reduced Retinal Ganglion Cell Dendrite Integrity Followed by Retinal Nerve Fiber Layer Thinning in a Laser-induced Monkey Ocular Hypertension Model

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SYSatoyo YoshidaNKNaoki Kishi

Key Points

  • The study aims to evaluate the integrity of retinal ganglion cells and changes in their dendrites during ocular hypertension in a monkey model.
  • Longitudinal evaluation of retinal ganglion cells in a laser-induced monkey ocular hypertension model over 8 weeks.
  • Assessment of MAP2 signaling and retinal nerve fiber layer thickness around the fovea.
  • Monitoring intraocular pressure (IOP) changes during the study period.
  • Significant decrease in retinal ganglion cell dendritic integrity was observed in laser-treated eyes over 8 weeks.
  • GCIPL thinning was noted before subsequent RNFL thinning.
  • Elevated intraocular pressure led to measurable reductions in retinal ganglion cell numbers.

Abstract

• Longitudinal evaluation revealed temporal changes in RGCs in a monkey OHT model. • GCIPL thinning was followed by RNFL thinning around the fovea by elevated IOP. • MAP2 + signal from RGC dendrites in the IPL was decreased in laser-treated eyes. • Significant RGC reduction occurred over the 8-week period by OHT induction. • Assessing RGC dendrite integrity is important in an early stage of glaucoma.

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Cite This Study

Yoshida et al. (2026) studied this question.

synapsesocial.com/papers/6a13e7e80e02ee3982d32925https://doi.org/10.1016/j.exer.2026.111086
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