Reduced Retinal Ganglion Cell Dendrite Integrity Followed by Retinal Nerve Fiber Layer Thinning in a Laser-induced Monkey Ocular Hypertension Model

Satoyo Yoshida; Naoki Kishi

doi:10.1016/j.exer.2026.111086

May 1, 2026Experimental Eye ResearchOpen Access

Reduced Retinal Ganglion Cell Dendrite Integrity Followed by Retinal Nerve Fiber Layer Thinning in a Laser-induced Monkey Ocular Hypertension Model

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Key Points

The study aims to evaluate the integrity of retinal ganglion cells and changes in their dendrites during ocular hypertension in a monkey model.
Longitudinal evaluation of retinal ganglion cells in a laser-induced monkey ocular hypertension model over 8 weeks.
Assessment of MAP2 signaling and retinal nerve fiber layer thickness around the fovea.
Monitoring intraocular pressure (IOP) changes during the study period.
Significant decrease in retinal ganglion cell dendritic integrity was observed in laser-treated eyes over 8 weeks.
GCIPL thinning was noted before subsequent RNFL thinning.
Elevated intraocular pressure led to measurable reductions in retinal ganglion cell numbers.

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Implication

Longitudinal evaluation reveals retinal ganglion cell changes in a monkey model of ocular hypertension, suggesting early glaucoma detection is essential.

Abstract

• Longitudinal evaluation revealed temporal changes in RGCs in a monkey OHT model. • GCIPL thinning was followed by RNFL thinning around the fovea by elevated IOP. • MAP2 + signal from RGC dendrites in the IPL was decreased in laser-treated eyes. • Significant RGC reduction occurred over the 8-week period by OHT induction. • Assessing RGC dendrite integrity is important in an early stage of glaucoma.

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Cite This Study

Yoshida et al. (2026) studied this question.

synapsesocial.com/papers/6a13e7e80e02ee3982d32925 https://doi.org/10.1016/j.exer.2026.111086

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Reduced Retinal Ganglion Cell Dendrite Integrity Followed by Retinal Nerve Fiber Layer Thinning in a Laser-induced Monkey Ocular Hypertension Model

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Reduced Retinal Ganglion Cell Dendrite Integrity Followed by Retinal Nerve Fiber Layer Thinning in a Laser-induced Monkey Ocular Hypertension Model

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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