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This review aims to identify global determinants and effective preventive strategies for type 1 diabetes mellitus in children.

Global determinants and preventive intervention strategies in pediatric type 1 diabetes mellitus

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This review aims to identify global determinants and effective preventive strategies for type 1 diabetes mellitus in children.
Conducted systematic review of literature across PubMed, Scopus, and Web of Science up to July 2025.
Included 32 studies, focusing on genetics, autoimmune markers, and preventive interventions in over 40,000 children.
Assessed study quality using the Cochrane risk-of-bias tool.
Presence of multiple islet autoantibodies and high-risk HLA genotypes (DR3/DR4, DQ8) were strong predictors of diabetes progression.
Early metabolic changes indicated higher risk, with continuous glucose monitoring effectively detecting subtle abnormalities.
Teplizumab showed potential in delaying progression, though response variances were noted, emphasizing the need for better-quality intervention trials.

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Systematic review highlights genetic and immune factors in pediatric diabetes, suggesting timely interventions.

Soliman et al. (2026) studied this question.

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