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May 25, 2026Tissue Engineering Part B Reviews

Gelatin Methacryloyl Hydrogels as a Multifaceted Platform for Promoting Nerve Regeneration

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Authors

SCShuaiwu ChenHeilongjiang University of Chinese MedicineYCYuqi CaoHeilongjiang University of Chinese MedicineYWYuanbo WangHeilongjiang University of Chinese Medicine

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Implication

Review demonstrates functionalization of gelatin methacryloyl hydrogels to enhance nerve regeneration, indicating innovative biomaterial applications.

Key Points

  • This review aims to explore the advancements in gelatin methacryloyl hydrogels for nerve tissue engineering and their functional applications.
  • Analyzed various functionalization strategies for GelMA hydrogels, including cell incorporation and neurotrophic factor delivery.
  • Discussed the integration of conductive materials and development of stimuli-responsive systems.
  • Highlighted the role of 3D bioprinting in creating complex nerve guidance conduits.
  • GelMA hydrogels exhibit enhanced biocompatibility and tunable properties for nerve repair.
  • Targeted drug delivery and electrical conductivity can significantly improve functional recovery in nerve injuries.
  • Innovative strategies provide pathways for personalized clinical treatments in neural repair.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a13e8680e02ee3982d3322fhttps://doi.org/10.1177/19373368261450049
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advancing Peripheral Nerve Regeneration: 3D Bioprinting of GelMA-Based Cell-Laden Electroactive Bioinks for Nerve Conduits2024 · 48 citations
  2. 2Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration2024 · 94 citations
  3. 3Oriented artificial niche provides physical-biochemical stimulations for rapid nerve regeneration2023 · 9 citations
  4. 4Nerve‐Derived Extracellular Matrix Promotes Neural Differentiation of Bone Marrow Stromal Cells and Enhances Interleukin‐4 Efficacy for Advanced Nerve Regeneration2025 · 7 citations
  5. 5Autonomic dysreflexia in spinal cord injury2020 · 83 citations