Key result
Phenoxybenzamine and metoprolol followed by surgery successfully treat pheochromocytoma-induced takotsubo cardiomyopathy mimicking AMI.
Case Report (n=1)
No
Pheochromocytoma can induce takotsubo cardiomyopathy mimicking acute myocardial infarction, and distinguishing the two is critical because isolated beta-blocker use can precipitate a life-threatening pheochromocytoma crisis.
Clinicians should exclude pheochromocytoma before beta-blockade in takotsubo mimicking MI; case report leaves open generalizability of alpha-then-beta blockade.
A 52-year-old Chinese woman was admitted to a cardiac intensive care unit (CCU) due to nausea, vomiting, and dyspnea, which began a day before her hospitalization. Metoprolol succinate and conventional treatment for acute myocardial infarction (AMI) were initially administered to the patient based on electrocardiogram (ECG) findings and elevated cardiac troponin I (cTnI). However, the following day, she developed aggravated nausea, vomiting, fever, sweating, a flushed face, a rapid heart rate, and a significant rise in blood pressure. Furthermore, ultrasonic cardiography (UCG) displayed takotsubo-like changes; nevertheless, ECG indicated inconsistent cTnI peaks with extensive infarction. After coronary computed tomography angiography (CTA) ruled out (AMI), and in conjunction with the uncommon findings, we strongly suspected that the patient had a secondary condition of pheochromocytoma-induced takotsubo cardiomyopathy (Pheo-TCM). In the meanwhile, the use of metoprolol succinate was promptly discontinued. This hypothesis was further supported by the subsequent plasma elevation of multiple catecholamines and contrast-enhanced computed tomography (CECT). After one month of treatment with high-dose Phenoxybenzamine in combination with metoprolol succinate, the patient met the criteria for surgical excision and successfully underwent the procedure. This case report demonstrated that pheochromocytoma could induce TCM and emphasized the significance of distinguishing it from AMI (in the context of beta-blocker usage and anticoagulant management).
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Zhang et al. (2023) conducted a case report in Pheochromocytoma-induced takotsubo cardiomyopathy (n=1). Phenoxybenzamine and metoprolol succinate followed by surgical excision was evaluated on Clinical recovery and successful surgical excision. A 52-year-old woman with pheochromocytoma-induced takotsubo cardiomyopathy mimicking acute myocardial infarction was successfully treated with phenoxybenzamine and metoprolol followed by surgery.
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