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May 25, 2026Comparative Clinical Pathology

Cardioprotective effects of diosmin against doxorubicin-induced dilated cardiomyopathy via Nrf2/TGF-β/PPAR-γ

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Key result

Diosmin attenuates doxorubicin-induced dilated cardiomyopathy in rats by modulating the Nrf2/TGF-β/PPAR-γ pathway.

  • n=40

Why the study?

The molecular mechanism and therapeutic potential of diosmin in doxorubicin-induced dilated cardiomyopathy remained to be explored.

Does diosmin improve doxorubicin-induced dilated cardiomyopathy in a rat model?

Population

Adult male Wistar rats divided into five groups (n = 8)

Comparison

Diosmin (25, 50, or 100 mg/kg/p.o.) with doxorubicin vs doxorubicin control and normal control

Design

Animal experimental study and molecular docking

Follow-up

28 days

Authors

UJUma JyotiChitkara UniversityATAman ThakurShobhit UniversitySDSushma DeviChitkara University

Discussion

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Implication

Hypothesis-generating for diosmin in doxorubicin cardiotoxicity; leaves open translation to human disease and clinical use.

Key Points

  • This study explores diosmin's molecular mechanisms and therapeutic potential against doxorubicin-induced cardiomyopathy.
  • Adult male Wistar rats (n=8) were divided into five treatment groups for 28 days.
  • Diosmin was administered at doses of 25 mg/kg, 50 mg/kg, and 100 mg/kg via oral gavage alongside doxorubicin.
  • Cardiotoxicity was assessed using oxidative and inflammatory markers, cardiac enzyme levels, and histopathological examination.
  • Diosmin significantly reduced oxidative stress markers and inflammatory cytokines.
  • Administration of diosmin resulted in improved cardiac function, with notable increases in Nrf2 and PPAR-γ, and decreased TGF-β levels.
  • Histological analysis showed near-normalization of cardiac hypertrophy and fibrosis in diosmin-treated rats.

Structured PICO

Does diosmin improve doxorubicin-induced dilated cardiomyopathy in a rat model?

P
Population
Adult male Wistar rats in a model of doxorubicin-induced dilated cardiomyopathy, n=40 (5 groups of n=8)
I
Intervention
Diosmin 25, 50, or 100 mg/kg/p.o. for 28 days
C
Comparator
Normal control and doxorubicin control
O
Outcome
Cardiotoxicity assessed using oxidative, inflammatory and cardiac enzyme markers as well as a histopathological studysurrogate

Diosmin demonstrates cardioprotective effects against doxorubicin-induced dilated cardiomyopathy in rats via modulation of the Nrf2/TGF-β/PPAR-γ pathway.

Cite This Study

Jyoti et al. (2026) studied Doxorubicin-induced dilated cardiomyopathy (n=40). Diosmin vs. Normal control and doxorubicin control was evaluated on Cardiotoxicity assessed using oxidative, inflammatory and cardiac enzyme markers and histopathology. Diosmin treatment (25-100 mg/kg) significantly improved cardiac dysfunction and attenuated doxorubicin-induced dilated cardiomyopathy in rats by modulating the Nrf2/TGF-β/PPAR-γ pathway.

synapsesocial.com/papers/6a13ea130e02ee3982d3372dhttps://doi.org/10.1007/s00580-026-03801-2
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