Key result
Piperine treatment significantly alleviated doxorubicin-induced cardiac injury and improved cardiac function in mice via activation of PPAR-γ.
Why the study?
Whether piperine could protect against doxorubicin-related cardiac injury was unclear.
Does piperine prevent doxorubicin-induced cardiac injury in mice?
Population
Mice with doxorubicin-induced acute cardiac injury
Comparison
Piperine (50 mg/kg) vs doxorubicin alone and PPAR-gamma antagonist combinations
Design
Preclinical animal and in vitro experimental study
Follow-up
3 weeks
Authors
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Hypothesis-generating for piperine in doxorubicin cardiotoxicity; human trials needed before any clinical use.
Does piperine prevent doxorubicin-induced cardiac injury in mice?
Piperine protects against doxorubicin-induced cardiotoxicity in mice by activating PPAR-γ, suggesting a potential therapeutic strategy for chemotherapy-induced heart failure.
Yan et al. (2019) studied Doxorubicin-induced cardiotoxicity. Piperine vs. Doxorubicin alone was evaluated on Cardiac injury and cardiac function. Piperine treatment significantly alleviated doxorubicin-induced cardiac injury and improved cardiac function in mice via activation of PPAR-γ.
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