Key result
Flow-mediated vasodilation, LVEF, and BMI predict treatment efficacy and guide therapy in pediatric orthostatic intolerance.
Why the study?
Biomarkers are increasingly being investigated to assess prognosis and guide individualized treatment to improve long-term outcomes in pediatric orthostatic intolerance.
Do biomarkers predict therapeutic efficacy and recurrence in children and adolescents with orthostatic intolerance?
Do biomarkers predict therapeutic efficacy and recurrence in children and adolescents with orthostatic intolerance?
Biomarkers offer a non-invasive, accessible means to predict treatment response and guide individualized therapy in pediatric patients with orthostatic intolerance.
May support individualized therapy in pediatric orthostatic intolerance; leaves open prospective validation before practice change.
Orthostatic intolerance (OI) refers to a series of symptoms that occur during upright standing, which can be relieved when returned to the supine position. OI is a common cause of syncope in children and adolescents. In recent years, more and more studies have been carried out to assess the prognosis of OI by using biomarkers, among which, flow-mediated vasodilation, left ventricular ejection fraction and fractional shortening, hemodynamic change during head-up tilt test, detection of 24-h urinary sodium excretion, body mass index, midregional pro-adrenomedullin, and erythrocytic H 2 S producing rate are relatively stable, inexpensive, and easy to obtain. With the help of biomarkers, individualized treatment can be carried out to improve the long-term prognosis of children and adolescents with OI. This article reviews the prognostic value of biomarkers in children and adolescents with OI.
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Yan et al. (2021) conducted a review in Orthostatic Intolerance. Biomarkers such as flow-mediated vasodilation, left ventricular ejection fraction, and body mass index can predict therapeutic efficacy and guide individualized treatment in pediatric orthostatic intolerance.
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