Myxomatous transformation of the mitral valve in the elderly can lead to intractable heart failure and may represent an aging response to mechanical stress.
Myxomatous mitral valve change may cause intractable HF in elderly; case report leaves open aging response to mechanical stress.
The clinical and pathological features of four patients with intractable heart failure, due to myxomatous change in the mitral valve, are described. It is suggested that this change may represent a response of ageing connective tissue to mechanical stress.
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Collins et al. (1976) studied this question.
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