Key result
The in-hospital death GRACE risk score independently predicted depressed left ventricular ejection fraction in patients with acute anterior myocardial infarction treated with primary PCI.
Why the study?
Despite rapid and complete reperfusion in AMI, inadequate recovery of left ventricular function may lead to decreased LVEF, prompting investigation into the predictive value of the GRACE score after acute anterior segment AMI.
Does the GRACE risk score predict depressed LVEF in patients with acute anterior segment AMI treated with primary PCI?
Observational (n=290)
No
Does the GRACE risk score predict depressed LVEF in patients with acute anterior segment AMI treated with primary PCI?
The GRACE risk score calculated at admission can independently predict the development of depressed left ventricular ejection fraction in patients with acute anterior myocardial infarction treated with primary PCI.
Answers are grounded in this paper and cite their sources.
May identify anterior AMI patients at higher LVEF risk post-PCI; extends GRACE utility but leaves open prospective validation.
Purpose: The aim of the study is to investigate the predictive value of GRACE score for left ventricular ejection fraction (LVEF) after acute anterior segment acute myocardial infarction (AMI). Despite rapid and complete reperfusion in AMI, inadequate recovery of left ventricular function may result in a decrease in LVEF.Materials and Methods: We retrospectively analyzed 712 patients presented with AMI and 290 patients were included. Patients were divided into two groups according to LVEF and a value <50% was defined as depressed EF group (group 1), a value ≥50% was defined as preserved EF group (group 2). The GRACE risk scores of all patients were calculated.Results: 132 patients were included in the group 1, 158 patients were included in the group 2. In-hospital death GRACE risk score and in-hospital death/MI GRACE risk score were higher in group 1. A significant negative correlation was found between risk scores and LVEF. In multivariate regression analysis, in-hospital death risk score, and in-hospital death/MI risk score were found to be independently predictors of depressed LVEF.Conclusion: GRACE risk score has a clinically important role predicting depressed LVEF in acute anterior segment AMI patients treated with primary PCI.
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Tosun et al. (2019) conducted an observational in Acute anterior ST-segment myocardial infarction (AAMI) (n=290). GRACE risk score was evaluated on Depressed left ventricular ejection fraction (<50%) (OR 1.10, 95% CI 1.05-1.15, p=<0.001). The in-hospital death GRACE risk score independently predicted depressed left ventricular ejection fraction in patients with acute anterior myocardial infarction treated with primary PCI.
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