Key result
Isolated systolic hypertension (SBP ≥160 mmHg) was associated with higher 8-year all-cause mortality (17.6% vs 7.7%), with each 1 mmHg increase raising mortality by ~1% (p<0.05).
Why the study?
Is isolated systolic hypertension associated with increased all-cause mortality in individuals with normal diastolic blood pressure?
Population
158,906 individuals from 14 communities around the United States screened for blood pressure, with a random…
Comparison
Isolated systolic hypertension vs Systolic blood pressure <160 mmHg
Design
Cohort
Follow-up
8 years
Authors
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Supports heightened awareness of mortality risk with isolated systolic hypertension; extends cohort evidence but leaves causality open for trials.
Cohort (n=158,906)
Yes
Is isolated systolic hypertension associated with increased all-cause mortality in individuals with normal diastolic blood pressure?
Effect estimate: 1% increase per 1 mmHg
Absolute Event Rate: 17.6% vs 7.7%
p-value: p=<0.05
Isolated systolic hypertension is relatively common and represents a significant independent risk factor for all-cause mortality.
Curb et al. (1985) conducted a cohort in Isolated systolic hypertension (n=158,906). Isolated systolic hypertension (SBP ≥160 mmHg) vs. Normal systolic blood pressure was evaluated on All-cause mortality (1% increase per 1 mmHg, p=<0.05). Isolated systolic hypertension (SBP ≥160 mmHg) was associated with higher 8-year all-cause mortality (17.6% vs 7.7%), with each 1 mmHg increase raising mortality by ~1% (p<0.05).
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