Key result
An elevated triglyceride-glucose (TyG) index was significantly associated with an increased risk of Activities of Daily Living (ADL) limitation (adjusted OR 1.23).
Why the study?
Although the TyG index is linked to mortality in cardiovascular diseases, its association with functional disability remains unclear.
Does a higher triglyceride-glucose (TyG) index increase the risk of functional disability in adults aged 45 and older?
Cross-Sectional (n=9,250)
Yes
Does a higher triglyceride-glucose (TyG) index increase the risk of functional disability in adults aged 45 and older?
Effect estimate: OR 1.23 (95% CI 1.16-1.30)
p-value: p=<0.001
Elevated triglyceride-glucose (TyG) index and its related obesity parameters are significantly associated with an increased risk of functional disability in middle-aged and older adults.
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Should not alter ADL risk assessment in practice; leaves open causal role of TyG index in functional decline.
Background The triglyceride-glucose (TyG) index, a marker of insulin resistance, is linked to mortality in coronary artery disease, ischemic stroke, and heart failure. However, its association with functional disability remains unclear. This study explored the relationship between the TyG index, its related parameters, and functional disability. Methods Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Functional disability was evaluated using the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scales. Multivariate logistic regression and restricted cubic spline (RCS) models were used to assess the associations between TyG-related indices and the risk of functional disability. Subgroup analyses stratified by age, sex, smoking, drinking, and diabetes were performed. Additionally, propensity score matching (PSM) was applied to ensure the robustness of the findings. Results The diagnosis rates were 1,510(16.32%) for ADL limited and 2,620(28.32%) for ADL-IADL limited. The TyG-related indices were significantly associated with ADL limited. [TyG index: Full adjusted OR = 1.23, 95%CI: 1.16–1.30, p < 0.001; TyG-BMI index: Full adjusted OR = 1.11, 95%CI: 1.05–1.18, p < 0.001; TyG-WC index: Full adjusted OR = 1.20, 95%CI: 1.13–1.27, p < 0.001; TyG-WHtR index: Full adjusted OR = 1.07, 95%CI: 1.01–1.14, p = 0.025]. The TyG-related indices were significantly associated with ADL-IADL limited. [TyG index: Full adjusted OR = 1.20, 95%CI: 1.14–1.26, p < 0.001; TyG-BMI index: Full adjusted OR = 1.13, 95%CI: 1.08–1.19, p < 0.001; TyG-WC index: Full adjusted OR = 1.14, 95%CI: 1.09–1.20, p < 0.001; TyG-WHtR index: Full adjusted OR = 1.13, 95%CI: 1.07–1.18, p < 0.001]. Conclusion Our findings indicated a trend that, TyG-related indices significantly associated with increased risks of ADL limited and ADL-IADL limited populations.
Wei et al. (2025) conducted a cross-sectional in Functional disability (ADL and IADL limitations) (n=9,250). Triglyceride-glucose (TyG) index was evaluated on Activities of Daily Living (ADL) limitation (OR 1.23, 95% CI 1.16-1.30, p=<0.001). An elevated triglyceride-glucose (TyG) index was significantly associated with an increased risk of Activities of Daily Living (ADL) limitation (adjusted OR 1.23).