August 1, 1985Circulation
Diastolic abnormalities in patients with hypertrophic cardiomyopathy: relation to magnitude of left ventricular hypertrophy.
Key result
Patients with hypertrophic cardiomyopathy and extensive left ventricular hypertrophy had significantly prolonged diastolic time intervals compared to those with mild hypertrophy (p<0.01).
Why the study?
What is the relationship between diastolic abnormalities and the magnitude of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy?
Population
52 patients with hypertrophic cardiomyopathy (HCM) and 22 normal subjects
Comparison
Digitized M mode echocardiography and… vs Normal subjects and patients with mild left…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Diastolic dysfunction in hypertrophic cardiomyopathy is related to the extent of left ventricular hypertrophy, but is also present in a substantial proportion of patients with only mild hypertrophy.
Study Design
Type
Observational (n=74)
Structured PICO
What is the relationship between diastolic abnormalities and the magnitude of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy?
P
Population
52 patients with hypertrophic cardiomyopathy (HCM) and 22 normal subjects
I
Intervention
Digitized M mode echocardiography and two-dimensional echocardiography
C
Comparator
Normal subjects and patients with mild left ventricular hypertrophy
O
Outcome
Echocardiographic indexes of diastolic function (time interval from minimum left ventricular internal dimension to mitral valve opening, time to peak rate of increase in left ventricular internal dimension, peak rate of posterior wall diastolic excursion)surrogate
Main Result
p-value: p=<0.01
Diastolic dysfunction in hypertrophic cardiomyopathy is related to the extent of left ventricular hypertrophy, but is also present in a substantial proportion of patients with only mild hypertrophy.
Cite This Study
Spirito et al. (1985) conducted an observational in Hypertrophic cardiomyopathy (n=74). Extensive left ventricular hypertrophy vs. Mild left ventricular hypertrophy and normal subjects was evaluated on Echocardiographic indexes of diastolic function (p=<0.01). Patients with hypertrophic cardiomyopathy and extensive left ventricular hypertrophy had significantly prolonged diastolic time intervals compared to those with mild hypertrophy (p<0.01).