Key result
Cardio-selective ß-blockers linked to ~18% lower risk of exaggerated exercise blood pressure response vs non-ß-blockers.
Why the study?
Despite the importance of exaggerated blood pressure response to exercise, limited data exist on the efficacy of ß-blockers in controlling it.
Does beta-blocker therapy prevent exaggerated blood pressure response during exercise in individuals undergoing treadmill tests?
Cross-Sectional (n=2,803)
No
Does beta-blocker therapy prevent exaggerated blood pressure response during exercise in individuals undergoing treadmill tests?
Absolute Event Rate: 11.1% vs 13.6%
p-value: p=0.026
Beta-blocker therapy is associated with a reduced incidence of exaggerated blood pressure response during exercise, with consistent effects across different cardio-selective beta-blocker types.
Associated with fewer exaggerated BP responses during exercise; leaves open need for randomized confirmation before guiding beta-blocker selection.
OBJECTIVE: The aim of this study was to analyze the role of various ß-blockers in managing exercise-induced blood pressure escalations, referred to as exaggerated blood pressure response (eBPR). Despite the importance of this phenomenon, there is limited data on the efficacy of ß-blockers in controlling eBPR. METHOD: Our retrospective cohort for this study comprised 2,803 individuals who underwent treadmill tests from January 2016 to February 2018. A further subgroup analysis of 1,258 patients receiving ß-blocker treatment was performed to evaluate the influence of different ß-blockers on eBPR. RESULTS: The results demonstrated that ß-blockers play a significant role in mitigating the occurrence of eBPR (P = 0.026), irrespective of the specific type of ß-blocker. Additionally, no significant variance was observed in the development of eBPR among the different ß-blocker groups (P = 0.532 for systolic blood pressure (BP); P = 0.068 for diastolic BP). This finding remained consistent even among the 992 hypertensive patients, where no notable association was found between the type of ß-blocker and the development of eBPR (P = 0.736 for systolic BP; P = 0.349 for diastolic BP). It is noteworthy that patients using ß-blockers had unique clinical and demographic attributes. CONCLUSION: Our study suggests that ß-blockers can potentially deter the development of eBPR during physical activity, a benefit that is consistent across all types of ß-blockers. The study sheds light on prospective randomized studies on the use of eBPR as a new treatment target.
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Gurbet Özge Mert (2024) conducted a cross-sectional in Exaggerated blood pressure response (eBPR) during exercise (n=2,803). Cardio-selective ß-blockers vs. Non-ß-blocker treatment was evaluated on Development of exaggerated blood pressure response (eBPR) (p=0.026). Cardio-selective ß-blockers significantly reduced the occurrence of exaggerated blood pressure response during exercise compared to non-ß-blocker treatment (11.1% vs 13.6%), with no significant difference observed among the specific types of ß-blockers.
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