Key result
Influenza A triggers earlier and more prolonged cardiovascular changes in female mice versus males.
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Indicates sex-specific influenza cardiovascular effects in mice; hypothesis-generating, requires human validation.
This study performed longitudinal cardiovascular measurements of influenza viral infection and identified sex difference in both physiological and molecular markers at peak disease.
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Martin et al. (2023) studied Influenza A infection (n=51). Influenza A/Puerto Rico/8/34 (PR8) infection vs. Mock infection with 1x PBS was evaluated. Influenza A infection in mice caused earlier and more prolonged cardiovascular physiological changes and greater weight loss in females compared to males, alongside distinct inflammatory gene expression.
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