Key result
NAFLD linked to ~12-fold higher CHD risk in patients without hypertension and diabetes.
Why the study?
The study was conducted to explore the relationship between coronary heart disease and nonalcoholic fatty liver disease in patients without hypertension and diabetes, focusing on predicting coronary heart disease.
Is nonalcoholic fatty liver disease associated with coronary heart disease in patients without hypertension and diabetes?
Cross-Sectional (n=78)
No
Is nonalcoholic fatty liver disease associated with coronary heart disease in patients without hypertension and diabetes?
Effect estimate: OR 11.870 (95% CI 3.32-42.406)
p-value: p=<0.001
NAFLD is significantly associated with the presence and severity of coronary heart disease in patients without traditional risk factors like hypertension and diabetes.
NAFLD may mark higher CHD risk independent of hypertension and diabetes; hypothesis-generating and requires prospective confirmation before clinical adoption.
This study was performed to explore the relationship between coronary heart disease (CHD) and nonalcoholic fatty liver disease (NAFLD) in patients without hypertension and diabetes with a focus on predicting CHD.In total, 78 consecutive patients without hypertension and diabetes who were suspected of CHD underwent coronary angiography (CAG) or computed tomography CAG. They were segregated into the CHD and non-CHD group according to the CAG or computed tomography angiography results. The Gensini score was calculated based on CAG results in the CHD group. All patients underwent ultrasonographic measurement of the liver, subcutaneous fat, and visceral fat thickness.The CHD and the Gensini score were significantly correlated with V1, V2, and NAFLD. As the grade of NAFLD increases, the Gensini score was increased. After correcting for confounding factors, NAFLD (B = 2.474, P < .001, 95% confidence interval: 3.32-42.406) and cholesterol (B = 1.176, P = 0.025, 95% confidence interval: 1.155-9.101) were predictor for CHD.The CHD is associated with NAFLD in the patients without hypertension and diabetes. The high-grade NAFLD may be predicted the risk of CHD in patients without hypertension and diabetes.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2020) conducted a cross-sectional in Suspected coronary heart disease without hypertension and diabetes (n=78). Nonalcoholic fatty liver disease (NAFLD) vs. Absence of NAFLD was evaluated on Presence of coronary heart disease (CHD) (OR 11.870, 95% CI 3.32-42.406, p=<0.001). In patients without hypertension and diabetes, nonalcoholic fatty liver disease was a significant independent predictor of coronary heart disease (OR 11.870).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: