Key result
Ibutilide fumarate significantly increased the conversion rate of atrial fibrillation or flutter to sinus rhythm compared with placebo (up to 57% for 1.0 mg vs 15% for placebo).
Why the study?
Does ibutilide fumarate improve the conversion of atrial arrhythmias to sinus rhythm in patients after cardiac surgery?
RCT (n=302)
blinded
randomized
Does ibutilide fumarate improve the conversion of atrial arrhythmias to sinus rhythm in patients after cardiac surgery?
Absolute Event Rate: 57% vs 15%
Ibutilide fumarate effectively and safely converts postoperative atrial fibrillation and flutter to sinus rhythm in a dose-dependent manner.
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Supports ibutilide for postoperative AF/flutter conversion; extends RCT efficacy data to cardiac surgery patients.
VanderLugt et al. (1999) conducted an RCT in Atrial fibrillation or flutter after cardiac surgery (n=302). Ibutilide fumarate vs. Placebo was evaluated on Restoration of sinus rhythm for any period of time by hour 1.5. Ibutilide fumarate significantly increased the conversion rate of atrial fibrillation or flutter to sinus rhythm compared with placebo (up to 57% for 1.0 mg vs 15% for placebo).
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