Key result
The Evolut PRO transcatheter aortic valve system showed significant improvement over the Evolut R in reducing paravalvular leak and pacemaker implantation in a single small study.
Why the study?
Newer transcatheter aortic valves have been developed to decrease paravalvular leak, permanent pacemaker implantation, and procedure-related complications, prompting a review of the self-expanding Evolut PRO system features.
Does the Evolut PRO transcatheter aortic valve system reduce paravalvular leak and pacemaker implantation compared to the Evolut R?
Does the Evolut PRO transcatheter aortic valve system reduce paravalvular leak and pacemaker implantation compared to the Evolut R?
The Evolut PRO transcatheter aortic valve system may offer improvements in paravalvular leak and pacemaker implantation rates compared to earlier generations, though larger studies are needed.
Should not yet alter TAVR valve choice; leaves open confirmation of Evolut PRO advantages in larger trials.
INTRODUCTION: Transcatheter aortic valves have evolved over the last 15 years. Second- and third- generation devices have considerably improved, and a range of newer devices have also been introduced with the aim of decreasing the incidence of paravalvular leak, reducing the need for permanent pacemaker implantation and minimizing procedure- and device-related complications. Areas covered: In this review, we highlight the special features of the latest generation of self-expanding Evolut PRO (Medtronic, Minneapolis, Minnesota) transcatheter aortic valve system. A detailed literature search on the Medtronic Evolut R and Evolut PRO transcatheter aortic valves was undertaken using Ovid, PubMed and Web of Science. Expert commentary: In a single, small study, the Evolut PRO has shown significant improvement over the Evolut R in terms of reduced paravalvular leak and pacemaker implantation. Larger scaled studies are needed to ascertain the performance of the Evolut PRO.
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Choudhury et al. (2018) conducted a review in Aortic valve disease. Evolut PRO transcatheter aortic valve system vs. Evolut R was evaluated on Paravalvular leak and pacemaker implantation. The Evolut PRO transcatheter aortic valve system showed significant improvement over the Evolut R in reducing paravalvular leak and pacemaker implantation in a single small study.
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