Normal aortic valves function as a constant resistor during stress, and progressive aortic stenosis demonstrates a highly linear relationship between rising transvalvular pressure gradient and falling transvalvular flow.
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Extends resistor model of normal aortic valves to stress; hypothesis-generating for human stenosis hemodynamics.
This study demonstrates that the normal aortic valve functions like a resistor with a proportional pressure loss ΔP versus transvalvular flow Q relationship. During dobutamine stress and progressive aortic banding, a "load line" of constant resistance characterizes the systemic circulation. Consequently, during stress conditions, the relative pressure loss over a stenotic aortic valve (the stress aortic valve index, SAVI) quantifies the relative reduction in maximal flow. Potentially, SAVI might optimize patient selection for procedures to treat aortic stenosis.
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Eerdekens et al. (2025) studied Aortic stenosis (simulated) (n=11). Dobutamine infusion and progressive aortic banding vs. Baseline (resting conditions) was evaluated on Coefficient of determination (R2) for transvalvular pressure loss versus flow relationship during dobutamine infusion.
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