Key result
Right atrial linear ablation guided by an advanced mapping system is feasible and safe for idiopathic drug-resistant AF, achieving a desirable clinical outcome in more than two-thirds of patients.
Why the study?
Does right atrial linear ablation guided by advanced mapping systems improve outcomes in patients with drug-resistant paroxysmal atrial fibrillation?
Does right atrial linear ablation guided by advanced mapping systems improve outcomes in patients with drug-resistant paroxysmal atrial fibrillation?
Advanced 3D mapping systems may safely and effectively guide right atrial linear ablation in selected patients with drug-refractory paroxysmal atrial fibrillation.
May support selected refractory AF cases; leaves open need for RCTs versus standard ablation.
Right atrial linear ablation has been used for the treatment of refractory atrial fibrillation (AF), with conflicting results. Conventional mapping techniques that have thus far been used for this purpose have resulted in lengthy procedure times and radiation exposure, while proving unsatisfactory in verifying the completeness of block lines. Alternative advanced three-dimensional non-fluoroscopic mapping systems that have recently been introduced may prove to be advantageous in transcatheter linear ablation to cure AF. This is because of their ability to improve the accuracy of ablation, to provide a highly detailed analysis of the atrial activation pattern once linear lesions have been created, and to reduce X-ray exposure time. Notwithstanding the lack of information on long-term follow up, the treatment of idiopathic drug-resistant AF using right atrial linear ablation guided by an advanced mapping system is, in our experience, both feasible and safe; a desirable clinical outcome may be achieved in more than two-thirds of patients, with some patients experiencing complete abolition of AF and others a statistically significant reduction in the number of symptomatic AF episodes. The use of advanced mapping systems in conjunction with atrial pacing on both sides of the lines of ablation is essential in order to assess completeness of the bidirectional block. Because procedural risks are very low, a first-step approach employing right atrial compartmentalization appears justified in selected patients with drug-refractory AF, who exhibit no evidence of focal substrates from which AF might initiate.
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Maurizio Gasparini (2001) conducted a review in Paroxysmal atrial fibrillation. Right atrial linear ablation guided by advanced mapping systems was evaluated on Clinical outcome (complete abolition of AF or reduction in symptomatic AF episodes). Right atrial linear ablation guided by an advanced mapping system is feasible and safe for idiopathic drug-resistant AF, achieving a desirable clinical outcome in more than two-thirds of patients.
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