What does this research mean for the field?

Aldosterone, angiotensin-converting enzyme, and BNP are produced locally in the failing human ventricle, with production levels proportional to the severity of ventricular dysfunction. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 2, 2001CirculationOpen Access

Aldosterone Production Is Activated in Failing Ventricle in Humans

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Why the study?

Is aldosterone produced in the failing human ventricle?

Structured PICO

Is aldosterone produced in the failing human ventricle?

Population

68 subjects, including 20 patients with left ventricular systolic dysfunction (LVSD), 25 patients with LV diastolic dysfunction (LVDD), and 23 control subjects.

Comparator

Control subjects without LV dysfunction

Outcome

Plasma levels of aldosterone, BNP, and angiotensin-converting enzyme in anterior interventricular vein (AIV), coronary sinus (CS), and aortic root (Ao)surrogate

Aldosterone, ACE, and BNP production are activated in the failing human ventricle in proportion to disease severity.

Discussion

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Implication

Supports local cardiac aldosterone production in LV dysfunction; hypothesis-generating for its role in progression and targeted therapy.

Cite This Study

Mizuno et al. (2001) studied this question.

synapsesocial.com/papers/6a145e3d7753e742da59df33 https://doi.org/10.1161/01.cir.103.1.72

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Aldosterone Production Is Activated in Failing Ventricle in Humans

Structured PICO

Discussion

Implication

Cite This Study

Aldosterone Production Is Activated in Failing Ventricle in Humans

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider