Key result
Baseline depressive symptoms in middle-aged men were associated with increased risk of coronary heart disease in the first 5 years (HR 1.43; 1.10-1.87) and stroke in the second 5 years.
Why the study?
Do baseline depressive symptoms increase the risk of first coronary heart disease and stroke events in healthy, middle-aged men?
Population
9,601 healthy, middle-aged men from France and Northern Ireland
Comparison
Presence of depressive symptoms at baseline vs Absence of depressive symptoms (lower quartiles)
Design
Cohort
Follow-up
10 years
Authors
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May warrant closer short-term CHD surveillance in middle-aged men; hypothesis-generating for temporal stroke links and needs prospective confirmation.
Cohort (n=9,601)
Yes
Do baseline depressive symptoms increase the risk of first coronary heart disease and stroke events in healthy, middle-aged men?
Effect estimate: HR 1.43 (95% CI 1.10-1.87)
Baseline depressive symptoms in healthy middle-aged men are associated with an increased risk of coronary heart disease in the short-term (first 5 years) and stroke in the long-term (second 5 years).
Majed et al. (2012) conducted a cohort in Cardiovascular disease risk (n=9,601). Baseline depressive symptoms vs. Absence of depressive symptoms was evaluated on First coronary heart disease event in the first 5 years of follow-up (HR 1.43, 95% CI 1.10-1.87). Baseline depressive symptoms in middle-aged men were associated with increased risk of coronary heart disease in the first 5 years (HR 1.43; 1.10-1.87) and stroke in the second 5 years.
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