Key result
Aortic stiffness, distensibility, and strain independently predict high SYNTAX scores in diabetic postmenopausal women.
Why the study?
Postmenopausal women and diabetic patients face increased CAD risk, and aortic stiffening increases cardiovascular morbidity and mortality, prompting investigation into whether aortic elasticity parameters relate to CAD severity assessed by SYNTAX score.
Do echocardiographic aortic elasticity parameters predict the severity of coronary artery disease assessed by SYNTAX score in postmenopausal diabetic women?
Cross-Sectional (n=200)
No
Do echocardiographic aortic elasticity parameters predict the severity of coronary artery disease assessed by SYNTAX score in postmenopausal diabetic women?
Simple echocardiography-derived aortic elasticity parameters can independently predict the severity and complexity of coronary artery disease in postmenopausal diabetic women.
Should not yet change practice in diabetic postmenopausal women; hypothesis-generating for aortic elasticity in CAD severity prediction.
BACKGROUND: Postmenopausal women are at increased risk of coronary artery disease (CAD). Diabetes Mellitus is a major risk factor for CAD. The stiffening of the aorta is associated with increased cardiovascular morbidity and mortality. We aimed to investigate the relation of aortic elasticity parameters to CAD severity assessed by SYNTAX score (SS) in diabetic postmenopausal women. The study prospectively included 200 consecutive diabetic postmenopausal women with CAD who underwent elective coronary angiography. Patients were classified into 3 groups based on SS, low-SS ≤ 22, intermediate-SS ≥ 23- ≤ 32, and high-SS ≥ 33. Echocardiographic aortic elasticity parameters, including aortic stiffness index (ASI), aortic strain (AS) (%) and aortic distensibility (AD) were obtained in all patients. RESULTS: Patients in the high SS group were older age and had a higher aortic stiffness. After adjusting different co-variates AD, AS, and ASI could be used as independent predictors of high SS with the following P-values (0.019, 0.016 and 0.010) and cut-off values (2.5, 3.6 and 2.9), respectively. CONCLUSIONS: In diabetic postmenopausal women, the simple echocardiography-derived aortic elasticity parameters might predict the severity and complexity of angiographic coronary lesions assessed by the SS.
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Naseem et al. (2023) conducted a cross-sectional in Type 2 Diabetes Mellitus and Coronary Artery Disease (n=200). Aortic elasticity parameters (Aortic distensibility, Aortic strain, Aortic stiffness index) vs. Low and intermediate SYNTAX score was evaluated on High SYNTAX score (≥ 33) (OR 0.765, 95% CI 0.507-0.913, p=0.010). Aortic stiffness index (OR 0.765), aortic distensibility (OR 1.236), and aortic strain (OR 1.964) independently predicted a high SYNTAX score in diabetic postmenopausal women.
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