October 21, 2002Circulation
How to Fix the Edge Effect of Catheter-Based Radiation Therapy in Stented Arteries
Key result
Extending radiation margins to 14.5 mm from each end of the stent minimized edge restenosis, and a higher dose (22 Gy) eliminated further intimal area increases at overlapped segments.
Why the study?
Do extended radiation margins and higher doses reduce edge restenosis (intimal area) in stented porcine coronary arteries treated with vascular brachytherapy?
Population
34 porcine stented coronary arteries
Comparison
Vascular brachytherapy withIr trains of 14 seeds… vs Vascular brachytherapy with 6 seeds providing…
Design
Preclinical
Follow-up
28 days
Authors
Discussion
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Member takes
Implication
Supports further preclinical optimization of brachytherapy; leaves open translation to human edge restenosis prevention.
Structured PICO
Do extended radiation margins and higher doses reduce edge restenosis (intimal area) in stented porcine coronary arteries treated with vascular brachytherapy?
P
Population
34 porcine stented coronary arteries
I
Intervention
Vascular brachytherapy with (192)Ir trains of 14 seeds (55 mm) providing extended radiation margins (14.5-27.5 mm) and higher dose (22 Gy), followed by an additional overlapping stent
C
Comparator
Vascular brachytherapy with 6 seeds (23 mm) providing shorter/no radiation margins (0-10 mm) and lower dose (15 Gy)
O
Outcome
Intimal area (IA) at the stent edge and overlapped segment at 28 dayssurrogate
In a porcine model, extending radiation margins and increasing the radiation dose minimized the edge-effect phenomenon and reduced intimal area in stented arteries treated with vascular brachytherapy.
Cite This Study
Cheneau et al. (2002) studied Edge stenosis in catheter-based vascular brachytherapy (n=34). Vascular brachytherapy with extended radiation margins and higher doses vs. Shorter radiation margins and lower doses was evaluated on Intimal area at the stent edge. Extending radiation margins to 14.5 mm from each end of the stent minimized edge restenosis, and a higher dose (22 Gy) eliminated further intimal area increases at overlapped segments.