Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 22, 2012European Journal of Heart FailureOpen Access

Right ventricular dysfunction (TAPSE ≤14 mm) in chronic systolic heart failure predicted all-cause mortality (HR 1.80; 95% CI 1.20-2.71) and increased the odds of chronic kidney disease.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Is right ventricular dysfunction associated with chronic kidney disease and all-cause mortality in outpatients with chronic systolic heart failure?

Population

373 outpatients with chronic systolic heart failure and left ventricular ejection fraction (LVEF) ≤45%

Design

Cohort

Follow-up

31 ± 24 months

Key result

Right ventricular dysfunction (TAPSE ≤14 mm) in chronic systolic heart failure predicted all-cause mortality (HR 1.80; 95% CI 1.20-2.71) and increased the odds of chronic kidney disease.

Authors

FDFrank Lloyd DiniRDRyan T. DemmerASAnca Simioniuc

Discussion

Loading...

Member takes

Overview

RV dysfunction may warrant closer surveillance in chronic systolic HF; hypothesis-generating for cardiorenal links and requires prospective validation.

Key Points

  • This research aims to evaluate the association between right ventricular dysfunction and chronic kidney disease in chronic systolic heart failure patients and its predictive value for survival.
  • Outpatients (n = 373) with chronic heart failure and left ventricular ejection fraction (LVEF) ≤45% were evaluated clinically and with echo-Doppler assessments.
  • Correlation analysis characterized the association between tricuspid annular plane systolic excursion (TAPSE) and estimated glomerular filtration rate (GFR).
  • Multivariable logistic and proportional hazards regression models assessed odds ratios for chronic kidney disease and hazard ratios for all-cause mortality.
  • TAPSE ≤14 mm increased the odds of estimated GFR <60 mL/min/1.73 m², OR = 2.51 (1.44-4.39), P < 0.0001.
  • TAPSE ≤14 mm predicted all-cause mortality, HR = 1.80 (1.20-2.71) after multivariable adjustment.
  • TAPSE and estimated GFR were significantly correlated (r = 0.38, P < 0.0001).

Study Design

Type

Cohort (n=373)

Structured PICO

Is right ventricular dysfunction associated with chronic kidney disease and all-cause mortality in outpatients with chronic systolic heart failure?

P
Population
373 outpatients with chronic systolic heart failure and left ventricular ejection fraction (LVEF) ≤45%
O
Outcome
Association between right ventricular dysfunction (assessed by TAPSE) and chronic kidney disease (estimated GFR <60 mL/min/1.73 m2), and all-cause mortalityhard clinical

Main Result

Effect estimate: HR 1.80 (95% CI 1.20-2.71)

Cite This Study

Dini et al. (2012) conducted a cohort in Chronic systolic heart failure (n=373). Right ventricular dysfunction (TAPSE ≤14 mm) was evaluated on All-cause mortality (HR 1.80, 95% CI 1.20-2.71). Right ventricular dysfunction (TAPSE ≤14 mm) in chronic systolic heart failure predicted all-cause mortality (HR 1.80; 95% CI 1.20-2.71) and increased the odds of chronic kidney disease.

synapsesocial.com/papers/6a149e2f0a38dee64c8ef86ahttps://doi.org/10.1093/eurjhf/hfr176
View Full Paper
Ask AI
Bookmark
Share