Why the study?
Does overexpression of Ang-(1-7) or ACE2 prevent pulmonary fibrosis and pulmonary hypertension in rat models?
Does overexpression of Ang-(1-7) or ACE2 prevent pulmonary fibrosis and pulmonary hypertension in rat models?
Overexpression of the ACE2/Ang-(1-7)/Mas axis provides cardiopulmonary protection against pulmonary fibrosis and pulmonary hypertension in rat models.
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Shenoy et al. (2010) studied Pulmonary Fibrosis and Pulmonary Hypertension. Lentiviral packaged Ang-(1-7) fusion gene or ACE2 cDNA vs. Empty virus (control) was evaluated on Right ventricular systolic pressure (RVSP) in MCT-induced pulmonary hypertension (p=<0.05).
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