February 26, 2009American Journal of Respiratory and Critical Care MedicineOpen Access

Evidence for Angiotensin-converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension

View Full Paper

Ask AI

Bookmark

Why the study?

Does XNT prevent pulmonary hypertension in a monocrotaline-induced rat model?

Population

Monocrotaline-induced pulmonary hypertension rat model

Comparison

Chronic treatment with XNT (1-[… vs Monocrotaline-treated rats without XNT treatment

Design

Preclinical

Authors

AFAnderson J. FerreiraGeneral / Preventive / Lipids VSVinayak ShenoyPenn State Milton S. Hershey Medical Center YYYoriko YamazatoUniversity of the Ryukyus

Discussion

Member takes

Implication

Supports ACE2 activation in experimental PH; hypothesis-generating for human disease with no current clinical implications.

Structured PICO

Does XNT prevent pulmonary hypertension in a monocrotaline-induced rat model?

Population

Monocrotaline-induced pulmonary hypertension rat model

Intervention

Chronic treatment with XNT (1-[(2-dimethylamino) ethylamino]-4-(hydroxymethyl)-7-[(4-methylphenyl) sulfonyl oxy]-9H-xanthene-9-one), a synthetic activator of ACE2

Comparator

Monocrotaline-treated rats without XNT treatment

Outcome

Right ventricular systolic pressure, right ventricular hypertrophy, pulmonary vessel wall thickness, and interstitial fibrosissurrogate

Activation of ACE2 by the small molecule XNT prevents the development of pulmonary hypertension in a rat model, suggesting a potential therapeutic target.

Cite This Study

Ferreira et al. (2009) studied this question.

synapsesocial.com/papers/6a758a2712165deef3dd7e88 https://doi.org/10.1164/rccm.200811-1678oc

View Full Paper

Ask AI

Bookmark

Evidence for Angiotensin-converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for Angiotensin-converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider