Why the study?
Does XNT reduce cardiac fibrosis and alter ERK signaling in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto control animals
Comparison
1-[ ethylamino]-4--7-[ sulfonyl… vs Control SHRs and Wistar-Kyoto control animals
Design
Preclinical
Follow-up
28 days
Authors
Loading...
XNT may reduce fibrosis via ACE2-ERK in hypertensive rats; leaves open clinical translation.
Does XNT reduce cardiac fibrosis and alter ERK signaling in spontaneously hypertensive rats?
XNT activates cardiac ACE2 and inhibits hypertension-induced cardiac fibrosis, which is associated with increases in angiotensin-(1-7) and inhibition of cardiac ERK signaling.
Ferreira et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: