Key result
Chronic administration of the ACE2 activator XNT improved endothelial function in hypertensive and diabetic rats by attenuating oxidative stress and eliciting Mas-mediated vasorelaxation.
Why the study?
Does the ACE2 activator XNT improve endothelial function in hypertensive and diabetic animal models?
Population
Spontaneously hypertensive rats, streptozotocin-induced diabetic rats, Mas knockout mice, and human aortic…
Design
Preclinical
Follow-up
4 weeks (in vivo)
Authors
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XNT effects remain preclinical; extends ACE2-Mas pathway data in hypertensive diabetic rats but leaves human translation open.
Does the ACE2 activator XNT improve endothelial function in hypertensive and diabetic animal models?
The small molecule ACE2 activator XNT improves endothelial function and reduces oxidative stress in preclinical models of hypertension and diabetes.
Fraga-Silva et al. (2013) studied Endothelial dysfunction in hypertension and diabetes. XNT (angiotensin-converting enzyme 2 activator) was evaluated on Endothelial function (vasorelaxant responses) and reactive oxygen species production. Chronic administration of the ACE2 activator XNT improved endothelial function in hypertensive and diabetic rats by attenuating oxidative stress and eliciting Mas-mediated vasorelaxation.
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