Key result
Nonadherence to antihypertensive medications in resistant hypertension was associated with a large clinic minus daytime ambulatory systolic BP difference (12.7 mm Hg vs 0.1 mm Hg in adherent patients).
Why the study?
The clinic-ambulatory blood pressure difference is influenced by multiple factors, but whether antihypertensive medication nonadherence also influences this difference was unknown.
Does medication nonadherence increase the difference between clinic and daytime ambulatory systolic blood pressure in patients with resistant hypertension?
RCT (n=77)
Does medication nonadherence increase the difference between clinic and daytime ambulatory systolic blood pressure in patients with resistant hypertension?
Absolute Event Rate: 12.7% vs 0.1%
A large difference between clinic and daytime ambulatory systolic blood pressure can help identify medication nonadherence in patients with resistant hypertension.
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May flag nonadherence in resistant hypertension; leaves open whether prospective use improves outcomes.
Hamdidouche et al. (2019) conducted an RCT in apparent resistant hypertension (n=77). Nonadherence to antihypertensive medications vs. Adherence to antihypertensive medications was evaluated on Clinic minus daytime ambulatory systolic BP difference. Nonadherence to antihypertensive medications in resistant hypertension was associated with a large clinic minus daytime ambulatory systolic BP difference (12.7 mm Hg vs 0.1 mm Hg in adherent patients).
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