What question did this study set out to answer?

To investigate the intraocular pressure dependence of corneal hysteresis and evaluate how corneal biomechanics relate to age, central corneal thickness, and applanation tonometry.

November 22, 2006Investigative Ophthalmology & Visual Science

Corneal Thickness- and Age-Related Biomechanical Properties of the Cornea Measured with the Ocular Response Analyzer

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Authors

AKAachal KotechaRoche (United Kingdom)AEAhmed ElsheikhUniversity of North Carolina at Chapel Hill CRCynthia R. RobertsOhio State University Hospital

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Implication

Comparative study reveals corneal biomechanical properties depend on age and thickness in untreated adults, indicating that intraocular pressure readings can be corrected for corneal stiffness.

Key Points

To investigate the intraocular pressure dependence of corneal hysteresis and evaluate how corneal biomechanics relate to age, central corneal thickness, and applanation tonometry.
Characterization study measured 105 untreated subjects (45 ocular hypertensive and 60 healthy; mean age 60, range 26–82) before and after intraocular pressure lowering with apraclonidine.
Validation study evaluated 144 eyes from 144 untreated subjects (mean age 58, range 19–83) using the Ocular Response Analyzer, Goldmann applanation tonometry, and ultrasound pachymetry.
The newly derived corneal constant factor (CCF) correlated positively with central corneal thickness (P < 0.0001) and negatively with age (P = 0.007; adjusted r² = 0.34).
Goldmann tonometry pressure was more strongly associated with CCF (r² = 0.13, P < 0.0001) than with central corneal thickness alone (r² = 0.06, P = 0.002).
Normalized Ocular Response Analyzer pressure was independent of central corneal thickness and agreed with Goldmann tonometry with a mean difference of 0.1 mm Hg (95% limits of agreement, -6.6 to +6.8 mm Hg).

Cite This Study

Kotecha et al. (2006) studied this question.

synapsesocial.com/papers/6a14ac89fc9ca4e5c9a6001e https://doi.org/10.1167/iovs.06-0557

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Implication

Comparative study reveals corneal biomechanical properties depend on age and thickness in untreated adults, indicating that intraocular pressure readings can be corrected for corneal stiffness.

Corneal Thickness- and Age-Related Biomechanical Properties of the Cornea Measured with the Ocular Response Analyzer

Discussion

Member takes

Implication

Key Points

Cite This Study

Corneal Thickness- and Age-Related Biomechanical Properties of the Cornea Measured with the Ocular Response Analyzer

Discussion

Member takes

Implication

Key Points

Cite This Study

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