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Offers synthesis of age-related CV physiology; leaves open targeted human trials before practice implications.
The sections in this article are: Cardiovascular Structure in Younger and Older Humans Arterial Structure and Mechanical Properties Cardiac Structure Ventricular–Vascular Coupling Myocardial and Cardiac Pump Function at Rest Integrated Regulation of Cardiac Function Cardiac Filling (Diastolic) Properties Cardiac Volumes and Ejection Fraction Myocardial Contractile Properties Heart Rate and Rhythm Cardiac Output Cardiovascular Reserve Postural Reflexes Isometric Exercise Dynamic Exercise Sympathetic Modulation of Cardiovascular Function Intact Organisms Cardiovascular Target Organ Response to β‐Adrenergic Stimulation with Aging Isolated Tissue or Cells Parasympathetic Modulation of Cardiovascular Function Cardiovascular Structure and Function in Younger and Older Animals Cardiac Structure Myocardial Stiffness Regulation of the Cardiac Contraction Similar Effects of Aging and Experimental Pressure Overload on Cardiac Regulatory Mechanisms and Gene Expression Possible Mechanisms of Altered Cardiac Gene Regulation with Aging Response of Older Rat Heart to Chronic Hemodynamic Overload Coronary Blood Flow, Oxygen Consumption, and Oxidative Metabolism Effect of Chronic Physical Conditioning on Cardiovascular Performance in Older Humans and Animals Studies in Humans Studies in Rodents Summary
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Edward G. Lakatta (1994) studied this question.
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