What is the clinical evidence from this study?

Study design: Other. Population: Coronary microembolization-induced myocardial injury (n=40). Intervention: Colchicine vs. Sham, CME alone, and CME + Colchicine + Compound C. Primary outcome: Cardiac function (LVEF, LVFS, LVEDd, LVESd) and myocardial injury markers (p=<0.05).

January 3, 2024BMC Cardiovascular DisordersOpen Access

Colchicine ameliorates myocardial injury induced by coronary microembolization through suppressing pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway

Q: What are the key findings of this study?

Colchicine pretreatment improved coronary microembolization-induced cardiac dysfunction and reduced myocardial injury by inhibiting cardiomyocyte pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway.

Q: What does this research mean for the field?

Colchicine pretreatment improves coronary microembolization-induced cardiac dysfunction and reduces myocardial injury by inhibiting cardiomyocyte pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Colchicine pretreatment improves microembolization-induced cardiac dysfunction by inhibiting pyroptosis via AMPK/SIRT1/NLRP3.

P<0.05
n=40

Why the study?

Coronary microembolization is linked to poor prognosis and myocardial pyroptosis, but the role of colchicine in pyroptosis-related myocardial injury induced by coronary microembolization remains unclear.

Does colchicine improve myocardial injury and cardiac dysfunction in a rat model of coronary microembolization?

Population

Sprague-Dawley rats subjected to coronary microembolization (10 rats for each group)

Comparison

Sham vs CME vs CME + colchicine vs CME + colchicine + compound C

Design

Controlled animal experimental study

Authors

HLHongqing LiGuangxi Medical University HYHuafeng YangFirst Affiliated Hospital of GuangXi Medical University ZQZhenbai QinCapital Medical University

Discussion

Member takes

Implication

Colchicine may attenuate pyroptosis in rat coronary microembolization; leaves open translation to human myocardial injury.

Structured PICO

Does colchicine improve myocardial injury and cardiac dysfunction in a rat model of coronary microembolization?

Population

40 male Sprague-Dawley (SD) rats (weight 250-300 g, 8 weeks old) subjected to a coronary microembolization (CME) model via left ventricular injection of microspheres.

Intervention

Colchicine 0.3 mg/kg by gavage seven days before and on the day of modeling.

Comparator

Sham operation (saline infusion) and CME without colchicine.

Outcome

Cardiac function (LVEF, LVFS, LVEDd, LVESd) at 9 hours post-modeling, serum myocardial injury markers (LDH, cTnT, CK-MB), and pyroptosis-related indicators.surrogate

Main Result

p-value: p=<0.05

Colchicine pretreatment ameliorates coronary microembolization-induced myocardial injury and cardiac dysfunction in rats by suppressing pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway.

Limitations

The CME model constructed using polyethylene microspheres cannot fully simulate the pathophysiological changes of CME due to atheromatous plaque rupture in the real world.
The study evaluated the protective effect of colchicine pretreatment only in the acute phase of CME, while middle and long-term therapeutic effects remain unknown.
No in vitro simulation experiments were completed using a primary cardiomyocyte model.

Cite This Study

Li et al. (2024) studied Coronary microembolization-induced myocardial injury (n=40). Colchicine vs. Sham, CME alone, and CME + Colchicine + Compound C was evaluated on Cardiac function (LVEF, LVFS, LVEDd, LVESd) and myocardial injury markers (p=<0.05). Colchicine pretreatment improved coronary microembolization-induced cardiac dysfunction and reduced myocardial injury by inhibiting cardiomyocyte pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway.

synapsesocial.com/papers/6a14b3acda53ecb65fb6ebb1 https://doi.org/10.1186/s12872-023-03697-8

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Colchicine ameliorates myocardial injury induced by coronary microembolization through suppressing pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Colchicine ameliorates myocardial injury induced by coronary microembolization through suppressing pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

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