Why the study?
It remained unknown which types of programmed cell death play the most dominant role in post-myocardial infarction.
Comparison
Permanent LAD ligation vs sham operation
Design
Preclinical animal model study
Follow-up
5-week
Authors
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Should not alter MI care; leaves open translation of PCD pathways from animal models to humans.
Pyroptosis is the dominant mode of programmed cell death driving left ventricular remodeling and dysfunction after myocardial infarction in a preclinical model.
Piamsiri et al. (2023) studied this question.
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