The partition of solutes between buffer solutions and solutions containing hyaluronic acid

This paper describes experiments which show that hyaluronic acid may affect markedly the partition of diffusible solutes between solutions that contain it and buffer solutions; this effect can be described as the exclusion of the solute from a part of the volume of solution occupied by the hyaluronic acid. Johnston (1955) suggested the occurrence of a large degree of exclusion to explain the effect of hyaluronic acid on the ultracentrifugal sedimentation of serum albumin; however,