Key result
Future murine studies of abdominal aortic aneurysms should focus on the treatment of established aneurysms rather than prevention to improve the translation of therapies to human patients.
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Shifting the focus of murine AAA models from prevention to the treatment of established aneurysms may improve the discovery of translatable clinical therapies.
While there is a growing body of evidence to suggest possible mechanisms for Abdominal Aortic Aneurysm (AAAs) formation, few murine studies have identified successful translational targets for AAA therapy in patient settings. This commentary seeks to address the need for murine studies to focus on treatment of established AAAs in multiple models to have the best possible outcome for future patient intervention.
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Morgan Salmon (2020) conducted an editorial in Abdominal Aortic Aneurysms. Future murine studies of abdominal aortic aneurysms should focus on the treatment of established aneurysms rather than prevention to improve the translation of therapies to human patients.
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