Key result
A multifaceted research approach combining experimental models, national registry analyses, and biomechanical simulations provides comprehensive insights into the pathogenesis and endovascular management of abdominal aortic aneurysms.
A comprehensive review of multifaceted approaches to abdominal aortic aneurysms, highlighting advancements in experimental models, national registry analyses of EVAR, and biomechanical simulations to improve treatment safety and efficacy.
The underlying mechanisms of abdominal aortic aneurysms (AAAs) are not fully understood. Given the multifactorial nature of AAA development and progression, a comprehensive approach is essential. Throughout my academic career, I conducted various studies on AAA. To better understand this mechanism, I initially developed an elastase-infused rat AAA model and applied it to nanoparticle drug delivery systems. While open surgery has traditionally been the standard treatment for AAA, endovascular aneurysm repair (EVAR) has seen significant advancements over the past 25 years. However, insufficient evidence exists regarding this novel treatment, particularly in Japan. To address this issue, we analyzed extensive datasets on EVAR using various registries, including the Japanese Committee for Stent Graft Management. Furthermore, through medical-engineering collaboration, simulation methods were utilized to generate evidence addressing clinical questions encountered in practice.
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Katsuyuki Hoshina (2025) conducted a review in Abdominal Aortic Aneurysm. Multifaceted research approaches (experimental, registry, simulation) was evaluated. A multifaceted research approach combining experimental models, national registry analyses, and biomechanical simulations provides comprehensive insights into the pathogenesis and endovascular management of abdominal aortic aneurysms.
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