Experimental animal models are crucial for understanding the pathophysiology of abdominal aortic aneurysms and developing new pharmacological and endovascular therapies.
Reinforces value of experimental AAA models for researchers; leaves open clinical translation of derived therapies.
Despite being a leading cause of death in the West, the pathophysiology of abdominal aortic aneurysms (AAA) is still incompletely understood. Pharmacotherapy to reduce the growth of small AAAs is limited and techniques for repairing aneurysms continue to evolve. Experimental models play a key role in AAA research, as they allow a detailed evaluation of the pathogenesis of disease progression. This review focuses on in vivo experimental models, which have improved our understanding of the potential mechanisms of AAA development and contributed to the advancement of new treatments.
No takes yet. Share an insight, caveat, or question.
Janice Tsui (2010) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: