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May 19, 2009Cardiovascular ResearchOpen Access

Treatment with statins, ACE inhibitors, antibiotics, and anti-inflammatory agents appears to inhibit the growth rate of AAA in humans, though large randomized studies are needed to confirm these effects.

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Why the study?

Does pharmacological therapy inhibit the growth rate or induce regression of abdominal aortic aneurysms?

Population

Patients with abdominal aortic aneurysm (AAA), particularly small AAAs, and experimental models

Design

Review

Authors

TMTeruki MiyakeRMRyuichi Morishita

Discussion

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Overview

May support pharmacological slowing of small AAA growth; leaves open confirmation by large RCTs before practice change.

Structured PICO

Does pharmacological therapy inhibit the growth rate or induce regression of abdominal aortic aneurysms?

P
Population
Patients with abdominal aortic aneurysm (AAA), particularly small AAAs, and experimental models
I
Intervention
Pharmacological agents including statins, angiotensin-converting enzyme-inhibitors, antibiotics, anti-inflammatory agents, and molecular pharmacological approaches
O
Outcome
AAA growth rate and regression of AAAsurrogate

Pharmacological therapies show promise in inhibiting small AAA growth and potentially inducing regression, but large randomized trials with long-term follow-up are required to establish a definitive treatment strategy.

Limitations

  • limited sample size in existing studies
  • limited follow-up period in existing studies

Cite This Study

Miyake et al. (2009) studied this question.

synapsesocial.com/papers/6a87a9848d26c625a50dcc24https://doi.org/10.1093/cvr/cvp155
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