Key result
Among 900 patients undergoing coronary angiography, 9% had normal coronary arteries, a finding predominantly observed in younger to middle-aged females with hyperlipidemia and a family history of CAD.
Observational (n=900)
No
Absolute Event Rate: 9% vs 91%
Normal coronary angiograms are an infrequent finding (9%) in the cath lab, most commonly seen in younger to middle-aged females with a family history of CAD and hyperlipidemia.
May refine pretest probability estimates in younger females; leaves open optimal diagnostic strategies pending prospective validation.
Objectives: To observe the clinical characteristics of patients having normalcoronary angiogram following an abnormal stress test or presented with chest pain indicatingcoronary angiogram. Study Design: A single center retrospective, descriptive study. Period:Coronary angiograms done from September 2015 to September 2016 were retrievedand reviewed for normal coronary arteries. Setting: Khatum-un-Nabyeen Heart Center.Methodology: Clinical profile of the patients having normal coronary angiogram was retrievedfrom hospital record. Results: Out of 900 angiograms reviewed, 81(9%) were having normalcoronary arteries. Mean age was 43±10 years. Females were 64.1%. Clinical characteristicof study group was as follows: smokers 32.09%, family history of premature coronary arterydisease 51.8%, hyperlipidemia 60.4% and hypertension 19.7%. Diabetes was present onlyin 20.9%. Among females: 19.2% were current users of oral contraceptives pills and 13.4%were post menopausal. Mean BMI was 25.4±4. Conclusion: Normal coronary angiogram isinfrequent observation in cardiac catheterization laboratories and mostly found in youngerto middle aged females. Family history of coronary artery disease and hyperlideimaare verycommon in such patients.
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Asghar et al. (2017) conducted an observational in Chest pain or acute coronary syndrome (n=900). Coronary angiography vs. Documented coronary artery disease was evaluated on Frequency of normal coronary angiogram. Among 900 patients undergoing coronary angiography, 9% had normal coronary arteries, a finding predominantly observed in younger to middle-aged females with hyperlipidemia and a family history of CAD.
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