Key result
Cardiac troponin I and T were significantly more sensitive than CKMB for detecting minor myocardial injury after elective PTCA (26% and 18% vs. 7%; P=0.00016 and P=0.015, respectively).
Why the study?
Are cardiac troponins more sensitive than CKMB for detecting minor myocardial injury in patients undergoing elective uncomplicated successful PTCA?
Observational (n=98)
Are cardiac troponins more sensitive than CKMB for detecting minor myocardial injury in patients undergoing elective uncomplicated successful PTCA?
Absolute Event Rate: 26% vs 7%
p-value: p=0.00016
Cardiac troponins, especially cTnI, are more sensitive than CKMB for detecting minor myocardial injury following elective uncomplicated PTCA, which is associated with longer inflation times, higher inflation pressures, and side-branch occlusion.
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Troponins may detect more minor injury than CKMB after elective PTCA; hypothesis-generating, prospective studies needed before practice change.
Saadeddin et al. (2001) conducted an observational in stable angina (n=98). Cardiac troponin I and T measurement vs. CKMB measurement was evaluated on frequency of abnormal marker levels after coronary intervention (p=0.00016). Cardiac troponin I and T were significantly more sensitive than CKMB for detecting minor myocardial injury after elective PTCA (26% and 18% vs. 7%; P=0.00016 and P=0.015, respectively).
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