Key result
Literature review and computational modeling suggest that selective synaptic failure or neuronal damage of inhibitory interneurons plays a critical role in generalized periodic discharges.
Population
Patients with metabolic encephalopathy and cerebral hypoxia/ischemia exhibiting Generalized periodic…
Design
Review
Authors
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May inform EEG interpretation in encephalopathies; leaves open validation of interneuron protection as therapeutic target.
Selective synaptic failure or neuronal damage of inhibitory interneurons likely plays a critical role in the pathophysiology of generalized periodic discharges.
Putten et al. (2015) conducted a review in Generalized periodic discharges in metabolic encephalopathy and cerebral hypoxia/ischemia. Computational model simulations was evaluated. Literature review and computational modeling suggest that selective synaptic failure or neuronal damage of inhibitory interneurons plays a critical role in generalized periodic discharges.
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