January 18, 2011Clinical Science
Aging and vascular endothelial function in humans
Key result
Advancing age contributes to cardiovascular disease risk through vascular endothelial dysfunction, primarily driven by oxidative stress and reduced nitric oxide bioavailability.
Population
Aging humans
Design
Review
Authors
Discussion
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Member takes
Implication
May inform lifestyle strategies to mitigate age-related endothelial dysfunction; leaves open need for targeted outcome trials.
Structured PICO
P
Population
Aging humans
This review highlights that aging-induced vascular endothelial dysfunction is primarily driven by oxidative stress and reduced nitric oxide bioavailability, and can be modulated by lifestyle factors.
Cite This Study
Seals et al. (2011) conducted a review in Vascular endothelial dysfunction and cardiovascular disease. Advancing age contributes to cardiovascular disease risk through vascular endothelial dysfunction, primarily driven by oxidative stress and reduced nitric oxide bioavailability.