Key result
Metabolic syndrome was associated with a significantly increased risk of incident aortic valve calcium (OR 1.67; 95% CI 1.21-2.31), but not with progression of established aortic valve calcium.
Why the study?
Does metabolic syndrome increase the risk of incident aortic valve calcium or its progression?
Cohort (n=5,723)
Does metabolic syndrome increase the risk of incident aortic valve calcium or its progression?
Effect estimate: OR 1.67 (95% CI 1.21-2.31)
Metabolic syndrome and diabetes are associated with an increased risk of developing new aortic valve calcium, suggesting they may be therapeutic targets for prevention.
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Metabolic syndrome may flag patients for aortic valve calcium surveillance; leaves open causal role and prevention trials.
Katz et al. (2009) conducted a cohort in Metabolic syndrome and aortic valve calcium (n=5,723). Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on Incident aortic valve calcium (AVC) or AVC progression (OR 1.67, 95% CI 1.21-2.31). Metabolic syndrome was associated with a significantly increased risk of incident aortic valve calcium (OR 1.67; 95% CI 1.21-2.31), but not with progression of established aortic valve calcium.
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