A clinical analysis and literature review of eleven cases with primary pulmonary angiosarcoma

Figures

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  Fig. 1. 2 cases with single lesion of PPAS patients. a. The right middle lobe of lung, lobulated soft tissue nodules, clear boundary, pleural traction; b. Postoperative image of left upper lung mass resection

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  Fig. 2. Cases with diffuse bilateral lung lesions of PPAS patients. a. Diffuse distribution of bilateral lungs, nodules and masses of different sizes, alveolar hemorrhage; b. Multiple nodules and masses of different sizes in bilateral lungs; patchy and grid shadow in left upper lobe of lung; c. Multiple nodules of different sizes scattered in bilateral lungs, irregular shape, burrs; d. Diffuse ground glass shadow in bilateral lungs, alveolar hemorrhage; e. Multiple nodules in bilateral lungs, right atrial metastasis and(f) brain metastasis

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  Fig. 3. 3 cases with pulmonary artery trunk filling defect of PPAS patients. a. PPAS involved right ventricular outflow tract, pulmonary trunk, right pulmonary artery and anterior mediastinum; b. Pulmonary artery trunk, left and right pulmonary artery, right upper lobe anterior segment filling defect; c. Multiple tumor thrombus in right ventricular outflow tract, pulmonary artery trunk, left and right pulmonary artery; the left upper lobe of lung involved

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  Fig. 4. 1 case with pulmonary artery filling defect and left lung resection of PPAS patients. a. Complete or incomplete embolization of bilateral multiple pulmonary arteries and local pulmonary infarction in the left lower lobe of lung; b. Postoperative image of left lung resection, right PEA and pulmonary artery tumor resection; c. The lesions of the right hilum and the posterior segment of the right upper lobe were larger than before, and the recurrence of PPAS was considered

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  Fig. 5. 4 cases 18-FDG concentration on PET-CT

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  Fig. 6. Immunohistochemical staining of PPAS patients. a. A case of CD31positive immunohistochemical staining; b. A case of CD34 positive immunohistochemical staining. c. A case of Fli1 immunohistochemical staining. d. A case of Ki67 20% immunohistochemical staining

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  Fig. 7. Specific gene markers: MDM2 positive in 2 cases

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  Fig. 8. Pulmonary angiosarcoma under low-power microscope and high-power microscope. (× 20, × 400). The tumor cells of different sizes were arranged in nests and scattered, and the nuclei were deformed and irregular. Scattered tumor giant cells could be seen

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  Fig. 9. Survival analysis of 11 PPAS patients