Key result
Enzyme antioxidants, particularly extracellular superoxide dismutase and bienzyme conjugates like SOD-CHS-CAT, represent a promising therapeutic strategy for cardioprotection against oxidative stress.
Enzyme antioxidants, particularly extracellular superoxide dismutase and its conjugates, represent promising therapeutic targets for cardioprotection against oxidative stress.
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May support antioxidant enzyme research in oxidative cardioprotection; hypothesis-generating and requires clinical trials before any practice consideration.
The focus in antioxidant research is on enzyme derivative investigations. Extracellular superoxide dismutase (EC-SOD) is of particular interest, as it demonstrates in vivo the protective action against development of atherosclerosis, hypertension, heart failure, diabetes mellitus. The reliable association of coronary artery disease with decreased level of heparin-released EC-SOD was established in clinical research. To create a base for and to develop antioxidant therapy, various SOD isozymes, catalase (CAT), methods of gene therapy, and combined applications of enzymes are used. Covalent bienzyme SOD-CHS-CAT conjugate (CHS, chondroitin sulphate) showed high efficacy and safety as the drug candidate. There is an evident trend to use the components of glycocalyx and extra-cellular matrix for target delivery of medical substances. Development of new enzyme antioxidants for therapeutic application is closely connected with progress in medical biotechnology, the pharmaceutical industry, and the bioeconomy.
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Максименко et al. (2012) conducted a review in Cardiovascular diseases. Enzyme antioxidants (EC-SOD, CAT, SOD-CHS-CAT conjugate) was evaluated. Enzyme antioxidants, particularly extracellular superoxide dismutase and bienzyme conjugates like SOD-CHS-CAT, represent a promising therapeutic strategy for cardioprotection against oxidative stress.
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