Key result
Angiotensin II blockers may act as effective adjunctive therapy for disease control in patients with rheumatoid arthritis by reducing inflammation, autoimmunity, and cardiovascular risk.
Why the study?
Do Angiotensin II blockers reduce inflammation and autoimmunity in patients with rheumatoid arthritis?
Do Angiotensin II blockers reduce inflammation and autoimmunity in patients with rheumatoid arthritis?
Angiotensin II blockers may serve as an effective adjunctive therapy in rheumatoid arthritis to control inflammation and reduce cardiovascular risk.
Should not yet alter RA management; leaves open adjunctive ARB benefit pending randomized confirmation.
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that is characterized by increased cardiovascular morbidity and mortality, independent of the traditional risk factors for cardiovascular disease. Although classically known for its role in the regulation of circulatory homeostasis, angiotensin II (Ang II) is recognized to act as a powerful proinflammatory mediator. Some research has showed that Ang II plays important roles in autoimmune diseases, including RA, systemic lupus erythematosus and multiple sclerosis. Ang II blockers prove effective in reducing inflammation and autoimmunity in rheumatic diseases and their relative safety, together with their effects for reducing the cardiovascular disease risk, suggest that Ang II blockers may at least act as effective adjunctive therapy for disease control in patients with RA. The present review focuses systematically on the potential impact of Ang II and its receptors on inflammation and immunomodulation in patients with RA.
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Chang et al. (2014) conducted a review in Rheumatoid arthritis. Angiotensin II blockers was evaluated. Angiotensin II blockers may act as effective adjunctive therapy for disease control in patients with rheumatoid arthritis by reducing inflammation, autoimmunity, and cardiovascular risk.
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