Key result
Increased circulating levels of myeloperoxidase significantly correlated with echocardiography parameters, supporting its use as a biomarker for early diagnosis of cardiac diastolic dysfunction.
Why the study?
Are Myeloperoxidase (MPO) serum levels correlated with echocardiographic parameters in patients with diastolic dysfunction and preserved systolic function?
Observational (n=91)
Are Myeloperoxidase (MPO) serum levels correlated with echocardiographic parameters in patients with diastolic dysfunction and preserved systolic function?
Myeloperoxidase serum levels correlate with echocardiographic parameters of diastolic dysfunction, suggesting its potential utility as a biomarker for early diagnosis and risk stratification in patients with preserved systolic function.
MPO may support early diastolic dysfunction detection in preserved EF; leaves open clinical adoption pending prospective validation.
The current study was conducted on a sample of 91 patients diagnosed with diastolic dysfunction (DD) with preserved systolic function caused by a painful chronic ischaemic cardiopathy - angina pectoris stable at the effort. The diagnosis was established following anamnesis, electrocardiogram, and echocardiography. Myeloperoxidase (MPO) serum levels were assessed in all patients and then these values were correlated with some of the echocardiography parameters that proved the mentioned diagnosis. In conclusion, the execution of this investigation triad (electrocardiogram, echocardiography, and MPO) allows: Stratifying the patients depending on the disease risk by early detecting of any possible DD with preserved systolic function. The use of the MPO increased circulating levels as a biomarker for diagnosis and risk due to the statistically significant correlation between those and the results of the other two aforementioned paraclinical investigation.
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Coculescu et al. (2018) conducted an observational in Diastolic dysfunction with preserved systolic function (n=91). Myeloperoxidase (MPO) testing was evaluated on Correlation between MPO serum levels and echocardiography parameters. Increased circulating levels of myeloperoxidase significantly correlated with echocardiography parameters, supporting its use as a biomarker for early diagnosis of cardiac diastolic dysfunction.
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